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Scheme for the selection of measurement uncertainty models in blood establishments' screening immunoassays.
- Source :
-
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2015 Feb; Vol. 52 (1), pp. 42-7. Date of Electronic Publication: 2014 Dec 29. - Publication Year :
- 2015
-
Abstract
- Blood establishments routinely perform screening immunoassays to assess safety of the blood components. As with any other screening test, results have an inherent uncertainty. In blood establishments the major concern is the chance of false negatives, due to its possible impact on patients' health. This article briefly reviews GUM and diagnostic accuracy models for screening immunoassays, recommending a scheme to support the screening laboratories' staffs on the selection of a model considering the intended use of the screening results (i.e., post-transfusion safety). The discussion is grounded on a "risk-based thinking", risk being considered from the blood donor selection to the screening immunoassays. A combination of GUM and diagnostic accuracy models to evaluate measurement uncertainty in blood establishments is recommended.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1473-0502
- Volume :
- 52
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
- Publication Type :
- Academic Journal
- Accession number :
- 25620757
- Full Text :
- https://doi.org/10.1016/j.transci.2014.12.018