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MicroRNAs in the biology and diagnosis of cholangiocarcinoma.
- Source :
-
Seminars in liver disease [Semin Liver Dis] 2015 Feb; Vol. 35 (1), pp. 55-62. Date of Electronic Publication: 2015 Jan 29. - Publication Year :
- 2015
-
Abstract
- Ever since their discovery, microRNAs (miRNAs) have been the subject of intense investigation of their roles in cells and tissues, both normal and disease state. Although some of the precise mechanisms of biogenesis and actions of miRNAs remain debatable, the fact that miRNAs are dysregulated in diseases such as cancer is undisputed. For many miRNA species, computational databases predict often numerous targets; however, experimental verification in vitro and in vivo is still lacking. For some miRNAs, species-specific targets have been validated; nevertheless, the precise mechanisms those targets act in and whether they are the only truly important ones remain to be discovered. The authors take a closer look at the current status of the role of miRNAs in the diagnosis and biology of cholangiocarcinomas where the perhaps biggest impact in the short term comes from the use of biomarkers in the early diagnosis.<br /> (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
- Subjects :
- Bile Duct Neoplasms diagnosis
Bile Duct Neoplasms metabolism
Biomarkers, Tumor metabolism
Cholangiocarcinoma diagnosis
Cholangiocarcinoma metabolism
Humans
MicroRNAs metabolism
Bile Duct Neoplasms genetics
Bile Ducts, Intrahepatic metabolism
Biomarkers, Tumor genetics
Cholangiocarcinoma genetics
MicroRNAs genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-8971
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Seminars in liver disease
- Publication Type :
- Academic Journal
- Accession number :
- 25632935
- Full Text :
- https://doi.org/10.1055/s-0034-1397349