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Multiple myeloma and glyphosate use: a re-analysis of US Agricultural Health Study (AHS) data.
- Source :
-
International journal of environmental research and public health [Int J Environ Res Public Health] 2015 Jan 28; Vol. 12 (2), pp. 1548-59. Date of Electronic Publication: 2015 Jan 28. - Publication Year :
- 2015
-
Abstract
- A previous publication of 57,311 pesticide applicators enrolled in the US Agricultural Health Study (AHS) produced disparate findings in relation to multiple myeloma risks in the period 1993-2001 and ever-use of glyphosate (32 cases of multiple myeloma in the full dataset of 54,315 applicators without adjustment for other variables: rate ratio (RR) 1.1, 95% confidence interval (CI) 0.5 to 2.4; 22 cases of multiple myeloma in restricted dataset of 40,719 applicators with adjustment for other variables: RR 2.6, 95% CI 0.7 to 9.4). It seemed important to determine which result should be preferred. RRs for exposed and non-exposed subjects were calculated using Poisson regression; subjects with missing data were not excluded from the main analyses. Using the full dataset adjusted for age and gender the analysis produced a RR of 1.12 (95% CI 0.50 to 2.49) for ever-use of glyphosate. Additional adjustment for lifestyle factors and use of ten other pesticides had little effect (RR 1.24, 95% CI 0.52 to 2.94). There were no statistically significant trends for multiple myeloma risks in relation to reported cumulative days (or intensity weighted days) of glyphosate use. The doubling of risk reported previously arose from the use of an unrepresentative restricted dataset and analyses of the full dataset provides no convincing evidence in the AHS for a link between multiple myeloma risk and glyphosate use.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Glycine toxicity
Health Surveys
Humans
Male
Middle Aged
Occupational Exposure statistics & numerical data
Prospective Studies
United States
Glyphosate
Agricultural Workers' Diseases chemically induced
Glycine analogs & derivatives
Herbicides toxicity
Multiple Myeloma chemically induced
Occupational Exposure adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1660-4601
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of environmental research and public health
- Publication Type :
- Academic Journal
- Accession number :
- 25635915
- Full Text :
- https://doi.org/10.3390/ijerph120201548