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Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2015 Mar 04; Vol. 27 (9), pp. 1593-9. Date of Electronic Publication: 2015 Jan 15. - Publication Year :
- 2015
-
Abstract
- A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Biocompatible Materials chemistry
Biopsy, Fine-Needle
Breast Neoplasms blood
Breast Neoplasms genetics
Cell Line, Tumor
Cell Separation methods
Cell Survival
Equipment Design
Gelatin chemistry
Humans
Lung Neoplasms blood
Lung Neoplasms genetics
Male
Materials Testing
Microfluidic Analytical Techniques methods
Models, Theoretical
Prostatic Neoplasms blood
Single-Cell Analysis instrumentation
Single-Cell Analysis methods
Stress, Mechanical
Temperature
Cell Separation instrumentation
Microfluidic Analytical Techniques instrumentation
Nanostructures chemistry
Neoplastic Cells, Circulating chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 27
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 25640006
- Full Text :
- https://doi.org/10.1002/adma.201404677