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Metal-mediated post-Ugi transformations for the construction of diverse heterocyclic scaffolds.
- Source :
-
Chemical Society reviews [Chem Soc Rev] 2015 Apr 07; Vol. 44 (7), pp. 1836-60. Date of Electronic Publication: 2015 Feb 05. - Publication Year :
- 2015
-
Abstract
- The Ugi-4CR is by far one of the most successful multicomponent reactions leading to high structural diversity and molecular complexity. However, the reaction mostly affords a linear peptide backbone, enabling post-Ugi transformations as the only solution to rigidify the Ugi-adduct into more drug like species. Not surprisingly, the development of these transformations, leading to new structural frameworks, has expanded rapidly over the last few years. As expected, palladium-catalyzed reactions have received the foremost attention, yet other metals, particularly gold complexes, are fast catching up. This tutorial review outlines the developments achieved in the past decade, highlighting the modifications that are performed in a sequential or domino fashion with emphasis on major concepts, synthetic applications of the derived products as well as mechanistic aspects.
- Subjects :
- Catalysis
Cyclization
Ligands
Heterocyclic Compounds chemistry
Metals chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1460-4744
- Volume :
- 44
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Chemical Society reviews
- Publication Type :
- Academic Journal
- Accession number :
- 25652577
- Full Text :
- https://doi.org/10.1039/c4cs00253a