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The importance of calciuria as lithogenic factors in patients with osteopenia/osteoporosis.
- Source :
-
International urology and nephrology [Int Urol Nephrol] 2015 Mar; Vol. 47 (3), pp. 445-9. Date of Electronic Publication: 2015 Feb 05. - Publication Year :
- 2015
-
Abstract
- Purpose: Recurrent kidney stones are associated with bone mineral density loss, altered bone remodeling markers, hypercalciuria and increased in fasting calcium/creatinine ratio. The objective was to determine biochemical alterations in urine in patients with osteopenia/osteoporosis without calcium kidney stones compared with patients with calcium kidney stones.<br />Methods: This is a cross-sectional study including 142 patients who were divided in two groups: Group 1 (patients with recurrent calcium kidney stones) and Group 2 (patients with osteopenia/osteoporosis in the lumbar spine or hip). Analyses of bone mineral density, calcium-phosphorous and bone metabolism and lithogenic risk factors in fasting urine samples and 24-h urine samples were performed. Statistical analysis was carried out with SPSS 17.0. A p ≤ 0.05 was considered statistically significant.<br />Results: Patients in Group 2 presented greater loss of bone mineral density and more elevated alkaline phosphatase, iPTH, phosphorous and β-crosslaps levels, as compared to patients in Group 1. However, Group 1 presented greater urine calcium, oxalate and uric acid and a higher proportion of hypocitraturia, hypercalciuria and hyperoxaluria, as compared to Group 2. Multivariate analysis revealed that advanced age and β-crosslaps levels are risk factors for bone mineral density loss, while low urinary calcium excretion was protective against bone demineralization.<br />Conclusion: Patients with osteopenia/osteoporosis without lithiasis present some urinary biochemical alterations. This would explain the lack of lithogenic activity, although low calcium excretion in 24-h urine samples is a protective factor against the loss of bone mineral density.
- Subjects :
- Adult
Age Factors
Alkaline Phosphatase urine
Bone Density
Bone Diseases, Metabolic complications
Bone Diseases, Metabolic urine
Calcium urine
Case-Control Studies
Collagen urine
Cross-Sectional Studies
Female
Humans
Hypercalciuria complications
Male
Middle Aged
Osteoporosis complications
Oxalic Acid urine
Parathyroid Hormone urine
Peptide Fragments urine
Phosphorus urine
Recurrence
Uric Acid urine
Hypercalciuria urine
Kidney Calculi etiology
Kidney Calculi urine
Osteoporosis urine
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2584
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International urology and nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 25652872
- Full Text :
- https://doi.org/10.1007/s11255-015-0918-z