Back to Search
Start Over
Associations between self-reported symptoms of prenatal maternal infection and post-traumatic stress disorder in offspring: evidence from a prospective birth cohort study.
- Source :
-
Journal of affective disorders [J Affect Disord] 2015 Apr 01; Vol. 175, pp. 241-7. Date of Electronic Publication: 2015 Jan 21. - Publication Year :
- 2015
-
Abstract
- Objective: Consistent evidence has linked a range of prenatal maternal infections with psychotic disorders in later life. However, the potential for this exposure to impact more common disorders requires further investigation.<br />Methods: Participants came from the Mater University Study of pregnancy, a longitudinal, pre-birth cohort study which recruited pregnant mothers from a Brisbane hospital between 1981 and 1984. At age 21, 2439 offspring completed the CIDI-Auto. Multivariate logistic regression was used to investigate associations of self-reported symptoms of prenatal infection with a range of DSM-IV anxiety and affective diagnoses, while also testing for gender interactions.<br />Results: In multivariate analyses, self-reported symptoms of prenatal genital infection predicted Post-traumatic stress disorders (OR=2.38, 95% CI: 1.14, 4.95) and social phobias (OR=1.93, 95% CI: 1.03, 3.61), in addition to evidence for a gender interaction by which males (OR=6.04, 95% CI: 2.00, 18.30) but not females were at greater risk for PTSD. Further analyses among those with PTSD revealed the relationship to be stronger when excluding those not exposed to trauma (OR=3.21, 95% CI: 1.53, 6.72).<br />Limitations: We were unable to clinically or serologically verify the presence and the type of prenatal genital infection.<br />Conclusion: This is the first study to show an association between self-reported symptoms of prenatal genital infections and two highly prevalent anxiety disorders among adult offspring. The relationship with PTSD was particularly strong and suggested that the exposure may primarily impact PTSD in males. Further research with the capacity to assess a fuller-range of specific prenatal infections is warranted to evaluate the potential of reducing the prevalence of these disorders.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Australia epidemiology
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Male
Phobic Disorders epidemiology
Phobic Disorders etiology
Pregnancy
Prevalence
Prospective Studies
Reproductive Tract Infections epidemiology
Risk Factors
Self Report
Sex Characteristics
Young Adult
Maternal Exposure
Pregnancy Complications, Infectious epidemiology
Prenatal Exposure Delayed Effects epidemiology
Prenatal Exposure Delayed Effects etiology
Stress Disorders, Post-Traumatic epidemiology
Stress Disorders, Post-Traumatic etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2517
- Volume :
- 175
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 25658498
- Full Text :
- https://doi.org/10.1016/j.jad.2015.01.011