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CTLA4 polymorphisms and de novo malignancy risk after renal transplantation in Chinese recipients.
- Source :
-
BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 986780. Date of Electronic Publication: 2015 Jan 15. - Publication Year :
- 2015
-
Abstract
- Genetic polymorphisms in cytotoxic T lymphocyte-associated antigen 4 (CTLA4) play an influential role in graft rejection and the long-term clinical outcome of organ transplantation. We investigated the association of five CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with de novo malignancy in 1463 Chinese renal transplantation (RT) recipients who underwent a 192-month follow-up. Multivariate analyses revealed that recipient rs231775 genotype is significantly associated with tumorigenesis (P = 0.012). Multiplicative interaction between rs231775 AA and possible risk factors of malignancy revealed two significant results: rs231775 AA × primary diseases and rs231775 AA × number of HLA-mismatch. The frequency of haplotype TACAG was significantly higher in the tumor group (17.07%) than that in the nontumor group (1.53%). In addition, aristolochic acid nephropathy (P = 0.003) and the time of discovery of tumor (P = 0.000) also were independently associated with tumorigenesis. Our data show that the CTLA4 genotype rs231775 AA may be one of risk factors for the development of malignancy and haplotype TACAG was susceptible haplotype in Chinese kidney transplant recipients.
- Subjects :
- Adult
Carcinogenesis pathology
Female
Gene Frequency genetics
Graft Rejection genetics
Haplotypes
Humans
Kidney Transplantation methods
Male
Risk
Risk Factors
Asian People genetics
CTLA-4 Antigen genetics
Carcinogenesis genetics
Genetic Predisposition to Disease genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2015
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 25667935
- Full Text :
- https://doi.org/10.1155/2015/986780