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Toxic and DNA-damaging activities of the fungicides mancozeb and thiram (TMTD) on human lymphocytes in vitro.
- Source :
-
Teratogenesis, carcinogenesis, and mutagenesis [Teratog Carcinog Mutagen] 1989; Vol. 9 (2), pp. 75-81. - Publication Year :
- 1989
-
Abstract
- The cytotoxic and mutagenic effects of the fungicides mancozeb and thiram were studied using human peripheral blood lymphocytes cultured in vitro with or without an S-9 mix microsomal metabolizing system. The results obtained suggested that the chemicals caused dose-dependent inhibition of thymidine uptake and unscheduled DNA synthesis on both resting and proliferating lymphocytes in the absence of the S-9 mix. In the presence of the S-9 mix, only thiram showed mutagenic activity by eliciting unscheduled DNA synthesis and a significantly higher frequency of sister chromatid exchanges than did controls.
Details
- Language :
- English
- ISSN :
- 0270-3211
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Teratogenesis, carcinogenesis, and mutagenesis
- Publication Type :
- Academic Journal
- Accession number :
- 2568023
- Full Text :
- https://doi.org/10.1002/tcm.1770090203