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Large T and small T antigens of Merkel cell polyomavirus.
- Source :
-
Current opinion in virology [Curr Opin Virol] 2015 Apr; Vol. 11, pp. 38-43. Date of Electronic Publication: 2015 Feb 11. - Publication Year :
- 2015
-
Abstract
- Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and highly lethal human skin cancer. A natural component of skin flora, MCV becomes tumorigenic only after integration into the host DNA together with specific mutations to the viral genome. Research on MCV large T (LT) and small T (sT) antigens, the only viral products expressed in MCC, shows that these major oncoproteins not only possess biochemical functions found in common with other polyomavirus T antigens, but also demonstrate new cellular targets not described in previous polyomavirus models. This review provides a map of the relevant functional motifs and domains in MCV T antigens that have been identified, highlighting their roles in tumorigenesis.<br /> (Copyright © 2015. Published by Elsevier B.V.)
Details
- Language :
- English
- ISSN :
- 1879-6265
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Current opinion in virology
- Publication Type :
- Academic Journal
- Accession number :
- 25681708
- Full Text :
- https://doi.org/10.1016/j.coviro.2015.01.009