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Association of the single-nucleotide polymorphism and haplotype of the complement receptor 1 gene with malaria.
- Source :
-
Yonsei medical journal [Yonsei Med J] 2015 Mar; Vol. 56 (2), pp. 332-9. - Publication Year :
- 2015
-
Abstract
- Purpose: Although the polymorphisms of erythrocyte complement receptor type 1 (CR1) in patients with malaria have been extensively studied, a question of whether the polymorphisms of CR1 are associated with severe malaria remains controversial. Furthermore, no study has examined the association of CR1 polymorphisms with malaria in Chinese population. Therefore, we investigated the relationship of CR1 gene polymorphism and malaria in Chinese population.<br />Materials and Methods: We analyzed polymorphisms of CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T in 509 patients with malaria and 503 controls, using the Taqman genotyping assay and PCR-direct sequencing.<br />Results: There were no significant differences in the genotype, allele and haplotype frequencies of CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T polymorphisms between patients with malaria and controls. Furthermore, there was no association of polymorphisms in the CR1 gene with the severity of malaria in Chinese population.<br />Conclusion: These findings suggest that CR1 gene rs2274567 G/A, rs4844600 G/A, and rs2296160 C/T polymorphisms may not be involved in susceptibility to malaria in Chinese population.
- Subjects :
- Adult
Alleles
Asian People
Case-Control Studies
China
Erythrocytes parasitology
Female
Genetic Predisposition to Disease
Genotype
Humans
Malaria ethnology
Male
Middle Aged
Receptors, Complement blood
Taq Polymerase
Haplotypes
Malaria genetics
Polymorphism, Single Nucleotide genetics
Promoter Regions, Genetic genetics
Receptors, Complement genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1976-2437
- Volume :
- 56
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Yonsei medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 25683978
- Full Text :
- https://doi.org/10.3349/ymj.2015.56.2.332