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From Mysterious Supernatant Entity to miRNA-150 in Antigen-Specific Exosomes: a History of Hapten-Specific T Suppressor Factor.
- Source :
-
Archivum immunologiae et therapiae experimentalis [Arch Immunol Ther Exp (Warsz)] 2015 Oct; Vol. 63 (5), pp. 345-56. Date of Electronic Publication: 2015 Feb 18. - Publication Year :
- 2015
-
Abstract
- Soon after the discovery of T suppressor cells by Gershon in 1970, it was demonstrated that one subpopulation of these lymphocytes induced by i.v. hapten injection suppresses contact sensitivity response mediated by effector CD4+ or CD8+ T cells in mice through the release of soluble T suppressor factor (TsF) that acts antigen specifically. Our experiments showed that biologically active TsF is a complex entity consisting of two subfactors, one antigen specific and other non-specific, produced by differently induced populations of cells. In following years, we found that the antigen-specific subfactor is a light chain of IgM antibody that is produced by B1a lymphocytes. However, the exact nature of non-specific part remained a mystery for about 30 years. Our current studies characterized TsF as regulatory miRNA-150 carried by T suppressor cell-derived exosomes that are antigen specific due to a surface coat of IgM antibody light chains produced by B1a cells. The present communication briefly summarizes our studies on TsF that led to discovery of regulating miRNA that acts antigen specifically to suppress immune response.
- Subjects :
- Animals
Culture Media, Conditioned metabolism
Exosomes immunology
Exosomes metabolism
Haptens immunology
Humans
Immune Tolerance
Immunoglobulin M metabolism
Mice
MicroRNAs immunology
Suppressor Factors, Immunologic immunology
B-Lymphocytes immunology
Dermatitis, Contact immunology
MicroRNAs metabolism
Suppressor Factors, Immunologic metabolism
T-Lymphocyte Subsets immunology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1661-4917
- Volume :
- 63
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archivum immunologiae et therapiae experimentalis
- Publication Type :
- Academic Journal
- Accession number :
- 25690461
- Full Text :
- https://doi.org/10.1007/s00005-015-0331-4