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Identification and characterization of a novel tick-borne flavivirus subtype in goats (Capra hircus) in Spain.
- Source :
-
The Journal of general virology [J Gen Virol] 2015 Jul; Vol. 96 (Pt 7), pp. 1676-81. Date of Electronic Publication: 2015 Feb 20. - Publication Year :
- 2015
-
Abstract
- In 2011, a neurological disease was reported in a herd of goats (Capra hircus) in Asturias, Spain. Initial sequencing identified the causative agent as louping ill virus (LIV). Subsequently, with the application of whole genome sequencing and phylogenetic analysis, empirical data demonstrates that the LIV-like virus detected is significantly divergent from LIV and Spanish sheep encephalitis virus (SSEV). This virus encoded an amino acid sequence motif at the site of a previously identified marker for differentiating tick-borne flaviviruses that was shared with a virus previously isolated in Ireland in 1968. The significance of these observations reflects the diversity of tick-borne flaviviruses in Europe. These data also contribute to our knowledge of the evolution of tick-borne flaviviruses and could reflect the movement of viruses throughout Europe. Based on these observations, the proposed name for this virus is Spanish goat encephalitis virus (SGEV), to distinguish it from SSEV.
- Subjects :
- Animals
Cluster Analysis
Encephalitis Viruses, Tick-Borne genetics
Encephalitis, Tick-Borne virology
Ireland
Molecular Sequence Data
Phylogeny
Sequence Homology
Spain
Encephalitis Viruses, Tick-Borne isolation & purification
Encephalitis, Tick-Borne veterinary
Genome, Viral
Goat Diseases virology
Goats virology
RNA, Viral genetics
Sequence Analysis, DNA
Subjects
Details
- Language :
- English
- ISSN :
- 1465-2099
- Volume :
- 96
- Issue :
- Pt 7
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 25701823
- Full Text :
- https://doi.org/10.1099/vir.0.000096