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Thaliporphine derivative improves acute lung injury after traumatic brain injury.
- Source :
-
BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 729831. Date of Electronic Publication: 2015 Feb 01. - Publication Year :
- 2015
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Abstract
- Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (PE) usually occurs in the TBI-induced ALI patients, we investigated the effects of a thaliporphine derivative, TM-1, on the expression of AQPs and histological outcomes in the lung following TBI in rats. TM-1 administered (10 mg/kg, intraperitoneal injection) at 3 or 4 h after TBI significantly reduced the elevated mRNA expression and protein levels of AQP1 and AQP4 and diminished the wet/dry weight ratio, which reflects PE, in the lung at 8 and 24 h after TBI. Postinjury TM-1 administration also improved histopathological changes at 8 and 24 h after TBI. PE was accompanied with tissue pathological changes because a positive correlation between the lung injury score and the wet/dry weight ratio in the same animal was observed. Postinjury administration of TM-1 improved ALI and reduced PE at 8 and 24 h following TBI. The pulmonary-protective effect of TM-1 may be attributed to, at least in part, downregulation of AQP1 and AQP4 expression after TBI.
- Subjects :
- Acute Lung Injury complications
Acute Lung Injury physiopathology
Animals
Aquaporin 1 biosynthesis
Aquaporin 1 genetics
Aquaporin 4 biosynthesis
Aquaporin 4 genetics
Brain Injuries complications
Brain Injuries physiopathology
Gene Expression drug effects
Humans
Rats
Acute Lung Injury drug therapy
Aporphines administration & dosage
Brain Injuries drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2015
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 25705683
- Full Text :
- https://doi.org/10.1155/2015/729831