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Prevalence and impact on outcome of electrocardiographic early repolarization patterns among stroke patients: a prospective observational study.
- Source :
-
Clinical research in cardiology : official journal of the German Cardiac Society [Clin Res Cardiol] 2015 Aug; Vol. 104 (8), pp. 666-71. Date of Electronic Publication: 2015 Feb 25. - Publication Year :
- 2015
-
Abstract
- Background: Early repolarization pattern (ER) gained attention as a risk factor for ventricular arrhythmia and sudden cardiac death in the general population. While electrocardiographic abnormalities are frequent findings in stroke patients, data on ER pattern in this population are lacking.<br />Methods: We assessed the prevalence of ER pattern in consecutive acute stroke patients at a tertiary stroke center. Functional outcome after 90 days was analyzed to determine the effect of an ER pattern on mortality. Multivariate logistic regression analysis was used to identify factors associated with an ER pattern.<br />Results: Out of 1141 consecutive stroke patients 771 patients remained for analysis after application of exclusion criteria. ER was observed in 62 (8.04%) patients. ER was more prevalent among subjects with intracerebral and subarachnoidal hemorrhage (13.0%) than among patients with ischemic stroke (7.0%; p = 0.024). Multiple regression analysis revealed QRS-duration (OR 0.972 95% CI 0.950-0.994, p = 0.012), QT-duration (OR 1.009, 95% CI 1.004-1.014, p = 0.001) and mechanical ventilation on admission (OR 0.320, 95% CI 0.136-0.752, p = 0.009) as independent predictors for ER. Overall ER on admission was not associated with increased mortality at 3-month follow-up (ER 11.3% vs. non-ER 9.2%; p = 0.582).<br />Conclusions: ER is frequently found among patients with acute cerebrovascular events and is more prevalent in patients with hemorrhagic compared to ischemic events. Our study yields no evidence that ER is associated with worse outcome or mortality after stroke.
- Subjects :
- Action Potentials
Aged
Arrhythmias, Cardiac mortality
Arrhythmias, Cardiac physiopathology
Brain Ischemia diagnosis
Brain Ischemia mortality
Brain Ischemia physiopathology
Brain Ischemia therapy
Chi-Square Distribution
Female
Germany epidemiology
Humans
Intracranial Hemorrhages diagnosis
Intracranial Hemorrhages mortality
Intracranial Hemorrhages physiopathology
Intracranial Hemorrhages therapy
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Prevalence
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Stroke diagnosis
Stroke mortality
Stroke physiopathology
Stroke therapy
Tertiary Care Centers
Time Factors
Arrhythmias, Cardiac diagnosis
Arrhythmias, Cardiac epidemiology
Brain Ischemia epidemiology
Electrocardiography
Heart Conduction System physiopathology
Intracranial Hemorrhages epidemiology
Stroke epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1861-0692
- Volume :
- 104
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical research in cardiology : official journal of the German Cardiac Society
- Publication Type :
- Academic Journal
- Accession number :
- 25707765
- Full Text :
- https://doi.org/10.1007/s00392-015-0831-6