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[Structure and radioprotective properties of a non-toxic polysaccharide from Heliantnus tuberosus L].
- Source :
-
Biofizika [Biofizika] 2014 May-Jun; Vol. 59 (3), pp. 439-45. - Publication Year :
- 2014
-
Abstract
- The data confirming non-toxicity of polysaccharide from Heliantnus tuberosus L. were gained in experimental studies on acute toxicity, the mass and cellularity of the immune system and cell viability of the lymphoid organs. The assumption of the absence of allergenicity was confirmed in the experiment of delayed-type hypersensitivity reaction . Dose reduction factor was specified in the experiment of absolute survival rates. The effectiveness of the substance as a radioprotector was confirmed. NMR spectrum was established, with the use of it a presumptive structure of a matter is restored.
- Subjects :
- Animals
Drug Evaluation, Preclinical
Magnetic Resonance Spectroscopy
Male
Mice
Mice, Inbred BALB C
Rabbits
Rats
Helianthus chemistry
Polysaccharides adverse effects
Polysaccharides chemistry
Polysaccharides pharmacology
Radiation-Protective Agents adverse effects
Radiation-Protective Agents chemistry
Radiation-Protective Agents pharmacology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0006-3029
- Volume :
- 59
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biofizika
- Publication Type :
- Academic Journal
- Accession number :
- 25715584