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Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone.

Authors :
Calzolari F
Michel J
Baumgart EV
Theis F
Götz M
Ninkovic J
Source :
Nature neuroscience [Nat Neurosci] 2015 Apr; Vol. 18 (4), pp. 490-2. Date of Electronic Publication: 2015 Mar 02.
Publication Year :
2015

Abstract

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

Details

Language :
English
ISSN :
1546-1726
Volume :
18
Issue :
4
Database :
MEDLINE
Journal :
Nature neuroscience
Publication Type :
Academic Journal
Accession number :
25730673
Full Text :
https://doi.org/10.1038/nn.3963