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Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone.
- Source :
-
Nature neuroscience [Nat Neurosci] 2015 Apr; Vol. 18 (4), pp. 490-2. Date of Electronic Publication: 2015 Mar 02. - Publication Year :
- 2015
-
Abstract
- We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.
Details
- Language :
- English
- ISSN :
- 1546-1726
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 25730673
- Full Text :
- https://doi.org/10.1038/nn.3963