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Polymorphisms in genes of the de novo lipogenesis pathway and overall survival of hepatocellular carcinoma patients undergoing transarterial chemoembolization.
- Source :
-
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2015; Vol. 16 (3), pp. 1051-6. - Publication Year :
- 2015
-
Abstract
- Aberrant expression of genes in de novo lipogenesis (DNL) pathway were associated with various cancers, including hepatocellular carcinoma (HCC). Single nucleotide polymorphisms (SNPs) of DNL genes have been reported to be associated with prognosis of some malignancies. However, the effects of SNPs in DNL genes on overall survival of HCC patients receiving transarterial chemoembolization (TACE) treatment are still unknown. In present study, nine SNPs in three genes (ACLY, ACACA and FASN) in DNL pathway were genotyped using the Sequenom iPLEX genotyping system in a hospital-based cohort with 419 HCC patients treated with TACE, and their associations with HCC overall survival were evaluated by Cox proportional hazard regression analysis under three genetic models (additive, dominant and recessive). Although we did not find any significant results in total analysis (all p>0.05), our stratified data showed that SNP rs9912300 in ACLY gene was significantly associated with overall survival of HCC patients with lower AFP level and SNP rs11871275 in ACACA gene was significantly associated with overall survival of HCC patients with higher AFP level. We further identified the significant interactions between AFP level and SNP rs9912300 or rs11871275 in the joint analysis. Conclusively, our data suggest that genetic variations in genes of DNL pathway may be a potential biomarker for predicting clinical outcome of HCC patients treated with TACE.
- Subjects :
- ATP Citrate (pro-S)-Lyase genetics
Acetyl-CoA Carboxylase genetics
Carcinoma, Hepatocellular genetics
Carcinoma, Hepatocellular pathology
Carcinoma, Hepatocellular therapy
Fatty Acid Synthase, Type I genetics
Female
Follow-Up Studies
Genotype
Humans
Liver Neoplasms genetics
Liver Neoplasms pathology
Liver Neoplasms therapy
Male
Middle Aged
Neoplasm Staging
Polymerase Chain Reaction
Prognosis
Survival Rate
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Hepatocellular mortality
Chemoembolization, Therapeutic
Lipogenesis genetics
Liver Neoplasms mortality
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2476-762X
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Asian Pacific journal of cancer prevention : APJCP
- Publication Type :
- Academic Journal
- Accession number :
- 25735330
- Full Text :
- https://doi.org/10.7314/apjcp.2015.16.3.1051