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Clinical reversible myelopathy in T-cell lymphoblastic lymphoma treated with nelarabine and radiotherapy: report of a case and review of literature of an increasing complication.

Authors :
Tisi MC
Ausoni G
Vita MG
Tartaglione T
Balducci M
Laurenti L
Chiusolo P
Hohaus S
Sica S
Source :
Mediterranean journal of hematology and infectious diseases [Mediterr J Hematol Infect Dis] 2015 Mar 01; Vol. 7 (1), pp. e2015025. Date of Electronic Publication: 2015 Mar 01 (Print Publication: 2015).
Publication Year :
2015

Abstract

Eleven cases of neurological defects in T-ALL patients treated with nelarabine have been described in the last 4 years, seven of these after stem cell transplantation (SCT) for T Lymphoblastic Lymphoma (T-LBL). Most of these patients had an unfavorable outcome or irreversible neurological damage. We now report the case of a 41-year-old woman suffering from T-LBL who presented with severe, but reversible myelopathy after receiving nelarabine-based treatment and mediastinal radiotherapy, and we provide a review of the literature on the topic.

Details

Language :
English
ISSN :
2035-3006
Volume :
7
Issue :
1
Database :
MEDLINE
Journal :
Mediterranean journal of hematology and infectious diseases
Publication Type :
Academic Journal
Accession number :
25745552
Full Text :
https://doi.org/10.4084/MJHID.2015.025