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Association between biomarkers of oxidative stress, trace elements, and cell proliferation index in patients with benign and malignant breast diseases.
- Source :
-
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer [J Environ Pathol Toxicol Oncol] 2015; Vol. 34 (1), pp. 1-10. - Publication Year :
- 2015
-
Abstract
- Objectives: To understand the association between biomarkers of oxidative stress, antioxidants, trace elements, and cell proliferation index in relation to the disease progression in the pathophysiology of breast diseases.<br />Design and Methods: Concentrations of markers of oxidative stress, antioxidants, trace elements, and cell proliferation index were evaluated in the patients with benign breast diseases, malignant breast diseases, and healthy volunteers as controls. Multinomial logistic regression analysis was used to identify the contribution of the selected indexes using odds ratio and associated confidence interval.<br />Results: The level of markers of oxidative stress (malondialdehyde [MDA]) and cell proliferation index were found to be significantly higher with significantly depleted levels of antioxidants and trace elements in breast cancer patients compared with control subjects as well as benign breast disease patients. A similar pattern of changes were observed between benign and control subjects.<br />Conclusion: An inadequate amount of antioxidant enzymes and trace elements may be an important contributing factor associated with oxidative stress leading to elevated levels of MDA and cell proliferation index in relation to disease progression and clinical stage in the pathophysiology of breast diseases.
- Subjects :
- Adult
Aged
Biomarkers
Breast Diseases metabolism
Breast Neoplasms metabolism
Catalase blood
Cell Proliferation
Female
Glutathione Peroxidase metabolism
Humans
Logistic Models
Middle Aged
Neoplasm Staging
Superoxide Dismutase metabolism
Breast Diseases pathology
Breast Neoplasms pathology
Oxidative Stress
Trace Elements analysis
Subjects
Details
- Language :
- English
- ISSN :
- 2162-6537
- Volume :
- 34
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 25746827
- Full Text :
- https://doi.org/10.1615/jenvironpatholtoxicoloncol.2015010089