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Hereditary breast cancer: an update on risk assessment and genetic testing in 2015.

Hereditary breast cancer: an update on risk assessment and genetic testing in 2015.

Authors :
Stuckey AR
Onstad MA
Source :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2015 Aug; Vol. 213 (2), pp. 161-5. Date of Electronic Publication: 2015 Mar 03.
Publication Year :
2015

Abstract

The last 5 years have brought significant innovation and advancement in the genetics of breast cancer. This clinical opinion aims to summarize and update current approaches to the care of women at risk for a hereditary predisposition to breast cancer. Implications of the BRCA mutation and several other hereditary syndromes will be discussed. Risk assessment and criteria for referral to cancer genetic professionals as well as high-risk screening and prophylactic options will be reviewed. Finally, the newly available genetic cancer panels and implications of mutations in some of these lesser known genes will be discussed. As the field of cancer genetics continues to evolve, the education of medical students, residents, and faculty will be paramount to identify appropriate candidates for genetic counseling and testing in conjunction with cancer genetic professionals.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1097-6868
Volume :
213
Issue :
2
Database :
MEDLINE
Journal :
American journal of obstetrics and gynecology
Publication Type :
Academic Journal
Accession number :
25747548
Full Text :
https://doi.org/10.1016/j.ajog.2015.03.003