Polysulfide promotes neuroblastoma cell differentiation by accelerating calcium influx.

Authors :: Koike S
Shibuya N
Kimura H
Ishii K
Ogasawara Y
Source :: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2015 Apr 10; Vol. 459 (3), pp. 488-92. Date of Electronic Publication: 2015 Mar 05.
Publication Year :: 2015
Abstract: Polysulfides are a typical type of bound sulfur, which is physiologically stable form of sulfur species, derived from the hydrogen sulfide (H2S) that is generated endogenously in cells. We previously reported that bound sulfur protects neuronal cells from oxidative injury. In the present study, we demonstrated that polysulfides inhibited cell growth and promoted neurite outgrowth in mouse neuroblastoma Neuro2A (N2A) cells. However, Na2S showed no effect on neurite outgrowth in N2A cells. Furthermore, 2-APB and SKF96365, which are typical transient receptor potential (TRP) channel inhibitors, suppressed the neurite outgrowth induced by Na2S4. These new findings suggest that bound sulfur could induce neurite outgrowth and cell differentiation of N2A cells by accelerating calcium influx.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)

Subjects :: Animals
Boron Compounds pharmacology
Cell Differentiation drug effects
Cell Differentiation physiology
Cell Line, Tumor
Imidazoles pharmacology
Ion Transport drug effects
Mice
Neurites drug effects
Neurites metabolism
Neurites pathology
Sulfides pharmacology
Transient Receptor Potential Channels antagonists & inhibitors
Calcium metabolism
Neuroblastoma metabolism
Neuroblastoma pathology
Sulfides metabolism

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