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Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience.
- Source :
-
Auris, nasus, larynx [Auris Nasus Larynx] 2015 Oct; Vol. 42 (5), pp. 377-81. Date of Electronic Publication: 2015 Mar 03. - Publication Year :
- 2015
-
Abstract
- Objective: Here we report our experience of patients with squamous cell carcinoma (SCC) of the nasal cavity and ethmoid sinus (NC&ES) together with an analysis of treatment outcomes.<br />Methods: A retrospective analysis was performed using data from 25 consecutive patients treated between 2000 and 2012. Four patients were diagnosed with T1, 3 with T2, 4 with T3, 7 with T4a, and 7 with T4b disease. No patient had lymph node metastasis.<br />Results: Twelve patients were treated with surgery with/without radiotherapy and with/without chemotherapy. Of these, 4 underwent endoscopic surgery without an open approach and 3 required an anterior skull base approach. Thirteen were treated with radiotherapy; 1 with radiotherapy alone, and 4 and 8 with intravenous and intra-arterial chemotherapy, respectively. The 5-yr overall survival for T1-3, T4a, and T4b disease was 53.9%, 71.4%, and 29.0%, respectively. The 5-yr disease-specific survival for T1-3, T4a, and T4b disease was 74.1%, 71.4%, and 29.0%, respectively.<br />Conclusion: Our treatment policy for patients with SCC of NC&ES, which basically follows the NCCN guideline, was considered to be appropriate. However, several points in terms of surgery and non-surgical approach remain to be solved through further research.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carboplatin administration & dosage
Carcinoma, Squamous Cell pathology
Chemoradiotherapy, Adjuvant
Cisplatin administration & dosage
Cohort Studies
Docetaxel
Endoscopy
Ethmoid Sinus pathology
Female
Fluorouracil administration & dosage
Head and Neck Neoplasms pathology
Humans
Infusions, Intra-Arterial
Male
Middle Aged
Nasal Cavity pathology
Neoplasm Staging
Nose Neoplasms pathology
Nose Neoplasms therapy
Organoplatinum Compounds administration & dosage
Otorhinolaryngologic Surgical Procedures
Paranasal Sinus Neoplasms pathology
Radiotherapy, Adjuvant
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck
Taxoids administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Squamous Cell therapy
Ethmoid Sinus surgery
Head and Neck Neoplasms therapy
Nasal Cavity surgery
Paranasal Sinus Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1476
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Auris, nasus, larynx
- Publication Type :
- Academic Journal
- Accession number :
- 25748513
- Full Text :
- https://doi.org/10.1016/j.anl.2015.02.005