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A highly efficient three-phase single drop microextraction technique for sample preconcentration.
- Source :
-
The Analyst [Analyst] 2015 May 07; Vol. 140 (9), pp. 3193-200. Date of Electronic Publication: 2015 Mar 10. - Publication Year :
- 2015
-
Abstract
- A highly efficient three-phase single drop microextraction (SDME) method is presented by using an organic-aqueous compound droplet. A coupling microdevice is designed to produce compound droplets in different sizes conveniently. In this way, the volume ratio of organic phase to aqueous phase in a compound droplet can be significantly reduced. Good operability and droplet stability were observed during extraction under vigorous stirring conditions. Five statins were used as model compounds and spiked in river water and human serum samples to evaluate the analytical performance of the proposed method. By using a 1.2 μL toluene-aqueous compound droplet (volume ratio 0.2 : 1), a 350 to 1712 fold enrichment of statins was obtained within 4 minutes. The results indicate that the proposed method is a very rapid and efficient sample pretreatment method, and is promising for automated and high-throughput applications.
- Subjects :
- Anticholesteremic Agents analysis
Anticholesteremic Agents isolation & purification
Equipment Design
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors analysis
Hydroxymethylglutaryl-CoA Reductase Inhibitors isolation & purification
Limit of Detection
Liquid Phase Microextraction economics
Sample Size
Toluene chemistry
Water chemistry
Water Pollutants, Chemical isolation & purification
Anticholesteremic Agents blood
Hydroxymethylglutaryl-CoA Reductase Inhibitors blood
Liquid Phase Microextraction instrumentation
Rivers chemistry
Water Pollutants, Chemical analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1364-5528
- Volume :
- 140
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 25756087
- Full Text :
- https://doi.org/10.1039/c4an02324b