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Assessment of early response to imatinib 800 mg after 400 mg progression by ¹⁸F-fluorodeoxyglucose PET in patients with metastatic gastrointestinal stromal tumors.
- Source :
-
Future oncology (London, England) [Future Oncol] 2015; Vol. 11 (6), pp. 953-64. - Publication Year :
- 2015
-
Abstract
- Introduction: Imatinib is the standard first-line therapy for advanced gastrointestinal stromal tumor. (18)F-fluorodeoxyglucose PET computed tomography (FDG PET/CT) shows a faster response than computed tomography in nonpretreated patients.<br />Patients & Methods: After disease progression on imatinib 400 mg, 16 patients were exposed to 800 mg. Tumor response was evaluated by FDG PET/CT on days 7 and 37. Primary objective was to correlate early metabolic response (EMR) with progression-free survival (PFS).<br />Results: EMR by FDG PET/CT scan was not predictive of PFS. Median PFS in these patients was 3 months. Overall survival was influenced by gastric primary site (p = 0.05).<br />Conclusion: The assessment of EMR by FDG PET/CT in patients with advanced gastrointestinal stromal tumor exposed to imatinib 800 mg was not predictive of PFS or overall survival.
- Subjects :
- Adult
Aged
Female
Fluorodeoxyglucose F18
Gastrointestinal Neoplasms mortality
Gastrointestinal Neoplasms pathology
Gastrointestinal Stromal Tumors mortality
Gastrointestinal Stromal Tumors pathology
Humans
Image Interpretation, Computer-Assisted
Male
Middle Aged
Neoplasm Metastasis
Prospective Studies
Protein Kinase Inhibitors administration & dosage
Survival Analysis
Tomography, X-Ray Computed
Treatment Outcome
Antineoplastic Agents administration & dosage
Gastrointestinal Neoplasms diagnosis
Gastrointestinal Neoplasms drug therapy
Gastrointestinal Stromal Tumors diagnosis
Gastrointestinal Stromal Tumors drug therapy
Imatinib Mesylate administration & dosage
Positron-Emission Tomography
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8301
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Future oncology (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 25760976
- Full Text :
- https://doi.org/10.2217/fon.14.292