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Biofilm-forming bacteria and quality of life improvement after sinus surgery.
- Source :
-
International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2015 Jul; Vol. 5 (7), pp. 643-9. Date of Electronic Publication: 2015 Mar 12. - Publication Year :
- 2015
-
Abstract
- Background: It remains unclear how much chronic rhinosinusitis (CRS) patients with bacterial biofilms can benefit from functional endoscopic sinus surgery (FESS). We aimed to evaluate whether biofilm-forming bacteria was associated with quality of life (QOL) improvement after FESS.<br />Methods: This retrospective cohort study included adult CRS patients who underwent FESS from 2008 to 2011. Sinus samples were taken to evaluate for biofilm-formation in vitro using a modified Calgary Biofilm Detection Assay. QOL was measured before FESS, and 1-month, 3-month, and 6-month after FESS using 22-item Sino-Nasal Outcome Test (SNOT-22) scores. Patients' characteristics and medications were collected. Clinical significant QOL change was defined as a difference of at least 0.5 standard deviation (SD) of baseline SNOT-22 score in the reference group.<br />Results: A total of 156 patients had complete data, and 15% had biofilm-forming bacteria (n = 24). Patients with biofilm-forming bacteria had significantly worse preoperative SNOT-22 scores compared to patients without biofilm-forming bacteria (48 ± 20 vs 38 ± 23, p = 0.048). Both groups had clinically significant QOL improvement after FESS, and the differences in their 1-month (23 ± 19 vs 17 ± 20) and 3-month (27 ± 18 vs 18 ± 19) post-FESS SNOT-22 scores were not significant. However, patients with biofilm-forming bacteria demonstrated significantly less QOL improvement than patients without biofilm-forming bacteria from pre-FESS to 6-month post-FESS visits after adjusting for clinical factors (35 ± 25 vs 14 ± 15; β-coefficient = 0.71; 95% confidence interval [CI], 0.13 to 1.28; p = 0.016).<br />Conclusion: CRS patients with biofilm-forming bacteria demonstrated clinically significant QOL improvement following FESS, but the degree of improvement was decreased overtime and became significantly worse than patients without biofilm-forming bacteria by 6-month follow-up. This QOL worsening was independent of other risk factors for CRS.<br /> (© 2015 ARS-AAOA, LLC.)
- Subjects :
- Adult
Female
Humans
Male
Middle Aged
Postoperative Period
Pseudomonas aeruginosa isolation & purification
Pseudomonas aeruginosa physiology
Retrospective Studies
Rhinitis psychology
Rhinitis surgery
Sinusitis psychology
Sinusitis surgery
Staphylococcus aureus isolation & purification
Staphylococcus aureus physiology
Streptococcus pneumoniae isolation & purification
Streptococcus pneumoniae physiology
Bacterial Physiological Phenomena
Biofilms
Nasal Surgical Procedures
Paranasal Sinuses surgery
Quality of Life psychology
Rhinitis microbiology
Sinusitis microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 2042-6984
- Volume :
- 5
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International forum of allergy & rhinology
- Publication Type :
- Academic Journal
- Accession number :
- 25763837
- Full Text :
- https://doi.org/10.1002/alr.21505