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Genipin-Crosslinked Gelatin-Based Emulgels: an Insight into the Thermal, Mechanical, and Electrical Studies.

Authors :
Mallick SP
Sagiri SS
Singh VK
Behera B
Thirugnanam A
Pradhan DK
Bhattacharya MK
Pal K
Source :
AAPS PharmSciTech [AAPS PharmSciTech] 2015 Dec; Vol. 16 (6), pp. 1254-62. Date of Electronic Publication: 2015 Mar 14.
Publication Year :
2015

Abstract

The present study discusses about the preparation and characterization (thermal, mechanical, and electrical) of the genipin-crosslinked gelatin emulgels. Emulgels have gained importance in recent years due to their improved stability than emulsions and ability to control the drug release. Mustard oil was used as the representative oil. A decrease in the enthalpy and entropy of the formulations was observed with the increase in the oil fraction. The mechanical studies suggested formation of softer emulgels as the oil fraction was increased. As the proportion of the oil fraction was increased in the emulgels, there was a corresponding increase in the impedance. The drug release properties from the emulgels were also studied. Ciprofloxacin was used as the model antimicrobial drug. The drug release was higher from the emulgels whose electrical conductivity was higher.

Details

Language :
English
ISSN :
1530-9932
Volume :
16
Issue :
6
Database :
MEDLINE
Journal :
AAPS PharmSciTech
Publication Type :
Academic Journal
Accession number :
25771735
Full Text :
https://doi.org/10.1208/s12249-014-0260-2