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Distinction of mesothelioma from adenocarcinoma. An immunohistochemical approach.
- Source :
-
Cancer [Cancer] 1985 Apr 15; Vol. 55 (8), pp. 1679-85. - Publication Year :
- 1985
-
Abstract
- The authors investigated the expression of keratin, carcinoembryonic antigen (CEA), and an epithelial marker derived from milk fat globule membranes in 12 mesotheliomas and 100 diverse adenocarcinomas with immunohistochemical methods. The authors employed a monoclonal antibody to keratin designated as AE1, as well as the following commercially available antisera: rabbit anti-whole human keratin, rabbit anti-CEA, and a monoclonal antibody to an epithelial factor designated as MFG-2. Expression of keratin was found in all the mesotheliomas and adenocarcinomas with antibody AE1 as well as with the rabbit antiserum; CEA was detectable in 65% of the adenocarcinomas but two mesotheliomas also reacted weakly. With antibody MFG-2, positive results were obtained in 85% of the adenocarcinomas and in none of the mesotheliomas. All of 64 (100%) breast-, lung- and ovary-derived adenocarcinomas immunostained positively with antibody MFG-2. This is of particular significance because pulmonary and ovarian adenocarcinoma frequently may be indistinguishable clinically and histologically from epithelial mesothelioma. The authors conclude that antikeratin antibodies are not useful in the distinction of adenocarcinoma from mesothelioma. Because of its greater sensitivity and specificity, MFG-2 is superior to CEA in this differential diagnosis.
- Subjects :
- Adenocarcinoma analysis
Antibodies, Monoclonal
Breast Neoplasms analysis
Carcinoembryonic Antigen analysis
Diagnosis, Differential
Female
Histocytochemistry
Humans
Immunoenzyme Techniques
Keratins analysis
Lung Neoplasms analysis
Male
Mesothelioma analysis
Ovarian Neoplasms analysis
Staining and Labeling
Adenocarcinoma pathology
Mesothelioma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 55
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 2579718
- Full Text :
- https://doi.org/10.1002/1097-0142(19850415)55:8<1679::aid-cncr2820550812>3.0.co;2-c