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Relationship between endothelial dysfunction and osteoprotegerin, vitamin D, and bone mineral density in patients with rheumatoid arthritis.
- Source :
-
Clinical and experimental rheumatology [Clin Exp Rheumatol] 2015 Mar-Apr; Vol. 33 (2), pp. 241-9. Date of Electronic Publication: 2015 Mar 10. - Publication Year :
- 2015
-
Abstract
- Objectives: We aimed to investigate whether the abnormalities in bone mineral density (BMD) that occur in patients with rheumatoid arthritis (RA) are associated with the presence of endothelial dysfunction.<br />Methods: Cross-sectional study encompassing 216 subjects (111 patients with RA and 105 age- and sex-matched controls) without history of cardiovascular disease. Endothelial function was determined by brachial artery flow-mediated dilatation (FMD) and BMD by dual x-ray absorptiometry (DXA) measurements. Plasma vitamin D and osteoprotegerin serum (OPG) levels were assessed in patients and controls. Multiple regression analysis was performed to study the relationship between BMD with endothelial function, taking into account vitamin D and OPG levels.<br />Results: After adjusting for traditional cardiovascular risk factors, vitamin D and OPG levels, BMD emerged as an independent factor associated with lower FMD values in controls, but not in patients with RA. Although OPG levels were inversely associated with FMD values in both RA patients and controls after adjusting for BMD, vitamin D showed this relationship only in the controls.<br />Conclusions: Whilst OPG is associated with endothelial function in RA patients and controls, vitamin D levels and BMD are related to endothelial function in controls but not in patients with RA.
- Subjects :
- Absorptiometry, Photon
Adult
Aged
Arthritis, Rheumatoid blood
Arthritis, Rheumatoid diagnosis
Arthritis, Rheumatoid physiopathology
Biomarkers blood
Cardiovascular Diseases blood
Cardiovascular Diseases diagnosis
Cardiovascular Diseases physiopathology
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Osteoporosis blood
Osteoporosis diagnosis
Osteoporosis physiopathology
Predictive Value of Tests
Risk Factors
Arthritis, Rheumatoid complications
Bone Density
Brachial Artery physiopathology
Cardiovascular Diseases etiology
Endothelium, Vascular physiopathology
Osteoporosis etiology
Osteoprotegerin blood
Vasodilation
Vitamin D blood
Subjects
Details
- Language :
- English
- ISSN :
- 0392-856X
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and experimental rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 25797915