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Nickel-catalyzed monofluoromethylation of aryl boronic acids.

Authors :
Su YM
Feng GS
Wang ZY
Lan Q
Wang XS
Source :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 May 11; Vol. 54 (20), pp. 6003-7. Date of Electronic Publication: 2015 Mar 24.
Publication Year :
2015

Abstract

Aryl boronic acids can be monofluoromethylated under nickel catalysis. The utility of this method is demonstrated by the monofluoromethylation of a borylated and acyl-protected derivative of the statin drug ezetimibe. Mechanistic investigations indicate that a fluoromethyl radical is involved in the Ni(I)/Ni(III) catalytic cycle.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1521-3773
Volume :
54
Issue :
20
Database :
MEDLINE
Journal :
Angewandte Chemie (International ed. in English)
Publication Type :
Academic Journal
Accession number :
25809786
Full Text :
https://doi.org/10.1002/anie.201412026