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Lower serum calcium level is associated with hemorrhagic transformation after thrombolysis.
- Source :
-
Stroke [Stroke] 2015 May; Vol. 46 (5), pp. 1359-1361. Date of Electronic Publication: 2015 Mar 26. - Publication Year :
- 2015
-
Abstract
- Background and Purpose: We aim to investigate whether lower admission serum calcium levels are associated with hemorrhagic transformation (HT) after intravenous thrombolysis (IVT).<br />Methods: A total of 362 patients treated with IVT was divided into 4 quartiles based on admission serum calcium levels (Q1[<2.16], Q2[2.16, 2.23], Q3[2.24, 2.31], and Q4[>2.31] mmol/L). HT was classified as hemorrhagic infarction and parenchymal hemorrhage. Logistic regression was applied to assess the association between serum calcium levels and the incidence of HT.<br />Results: Compared with Q4, HT was more common in Q1 (odds ratio, 2.580; 95% CI, [1.258-5.292]; P=0.010), Q2 (odds ratio, 2.382; 95% CI, [1.163-4.877]; P=0.018), and Q3 (odds ratio, 2.293; 95% CI, [1.133-4.637]; P=0.021). Hemorrhagic infarction was more common in Q1 (P=0.037), and Q2 (P=0.018), compared with Q4, and parenchymal hemorrhage was more common in Q1 (P=0.029) than Q4.<br />Conclusions: Lower admission serum calcium level is independently associated with HT after IVT, and this hypothesis needs larger confirmatory trials.<br /> (© 2015 American Heart Association, Inc.)
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 46
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 25813194
- Full Text :
- https://doi.org/10.1161/STROKEAHA.115.008992