The role of TRPV1 in improving VSMC function and attenuating hypertension.

Authors :: Zhang MJ
Yin YW
Li BH
Liu Y
Liao SQ
Gao CY
Li JC
Zhang LL
Source :: Progress in biophysics and molecular biology [Prog Biophys Mol Biol] 2015 Mar; Vol. 117 (2-3), pp. 212-216. Date of Electronic Publication: 2015 Mar 23.
Publication Year :: 2015
Abstract: The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin. Currently, cumulative studies have demonstrated an interesting link between TRPV1 and cardiovascular diseases, including hypertension. Additionally, the protective effect of TRPV1 against hypertension and its related disorders has been proved to be partly involved with the improved action of vascular smooth muscle cells (VSMCs). This review focuses on the current knowledge of TRPV1 in improving VSMC function and attenuating hypertension.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)