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Brain-derived neurotrophic factor levels in first episode of psychosis: A systematic review.

Authors :
Toll A
Mané A
Source :
World journal of psychiatry [World J Psychiatry] 2015 Mar 22; Vol. 5 (1), pp. 154-9.
Publication Year :
2015

Abstract

Aim: To systematically review studies measuring peripheric brain-derived neurotrophic factor (BDNF) levels on first-episode psychosis patients and variables related to them.<br />Methods: A systematic search was made of articles published in the Medline database from 2002 up to June 2014. Included are original studies that report enzyme-linked immunosorbent assay measurement of BDNF levels in serum or plasma in patients with a diagnosis of first episode psychosis (FEP) and age- and gender- matched healthy controls.<br />Results: Of the initially identified 147 articles, only 18 satisfied the inclusion criteria. Of this, 15 found a significant reduction in patients with FEP compared with age- and gender - matched controls.<br />Conclusion: Peripheral BDNF levels are generally reduced in FEP patients. There are some factors that may influence BDNF levels that need to be further studied. Furthermore, a future meta-analysis in this topic is needed.

Details

Language :
English
ISSN :
2220-3206
Volume :
5
Issue :
1
Database :
MEDLINE
Journal :
World journal of psychiatry
Publication Type :
Academic Journal
Accession number :
25815265
Full Text :
https://doi.org/10.5498/wjp.v5.i1.154