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Dextrin-coated zinc substituted cobalt-ferrite nanoparticles as an MRI contrast agent: In vitro and in vivo imaging studies.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2015 May 01; Vol. 129, pp. 15-20. Date of Electronic Publication: 2015 Mar 14. - Publication Year :
- 2015
-
Abstract
- Application of superparamagnetic iron oxide nanoparticles (NPs) as a negative contrast agent in magnetic resonance imaging (MRI) has been of widespread interest. These particles can enhance contrast of images by altering the relaxation times of the water protons. In this study, dextrin-coated zinc substituted cobalt-ferrite (Zn0.5Co0.5Fe2O4) NPs were synthesized by a co-precipitation method, and the morphology, size, structure and magnetic properties of the NPs were investigated. These NPs had superparamagnetic behavior with an average size of 3.9 (±0.9, n=200)nm measured by transmission electron microscopy. Measurements on the relaxivities (r2 and r2(*)) of the NPs were performed in vitro by agarose phantom. In addition, after subcutaneous injection of the NPs into C540 cell line in C-57 inbred mice, the relaxivities were measured in vivo by a 1.5T MRI system. These NPs could effectively increase the image contrast in both T2-and T2(*)-weighted samples.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Female
In Vitro Techniques
Mice
Mice, Inbred C57BL
Microscopy, Electron, Transmission
Neoplasms, Experimental metabolism
Particle Size
Protons
Tissue Distribution
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Cobalt chemistry
Contrast Media pharmacokinetics
Dextrins chemistry
Ferric Compounds chemistry
Magnetic Resonance Imaging methods
Neoplasms, Experimental pathology
Phantoms, Imaging
Zinc chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 129
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 25819361
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2015.03.021