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Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2015 May 01; Vol. 129, pp. 39-46. Date of Electronic Publication: 2015 Mar 14. - Publication Year :
- 2015
-
Abstract
- Theranostic delivery systems are nanostructures that combine the modality of therapy and diagnostic imaging. Polymeric micro- and nanobubbles, spherical vesicles containing a gas core, have been proposed as new theranostic carriers for MRI-guided therapy. In this study, chitosan nanobubbles were purposely tuned for the co-delivery of prednisolone phosphate and a Gd(III) complex, as therapeutic and MRI diagnostic agent, respectively. Perfluoropentane was used for filling up the internal core of the formulation. These theranostic nanobubbles showed diameters of about 500nm and a positive surface charge that allows the interaction with the negatively charged Gd-DOTP complex. Pluronic F68 was added to the nanobubble aqueous suspension as stabilizer agent. The encapsulation efficiency was good for both the active compounds, and a prolonged drug release profile was observed in vitro. The effect of ultrasound stimulation on prednisolone phosphate release was evaluated at 37°C. A marked increase on drug release kinetics with no burst effect was obtained after the exposure of the system to ultrasound. Furthermore, the relaxivity of the MRI probe changed upon incorporation in the nanobubble shell, thereby offering interesting opportunity in dual MRI-US experiments. The ultrasound characterization showed a good in vitro echogenicity of the theranostic nanobubbles. In summary, chitosan drug-loaded nanobubbles with Gd(III) complex bound to their shell might be considered a new platform for imaging and drug delivery with the potential of improving anti-cancer treatments.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Contrast Media pharmacokinetics
Hemoglobins analysis
Humans
In Vitro Techniques
Nanostructures chemistry
Organometallic Compounds pharmacokinetics
Organophosphorus Compounds pharmacokinetics
Tissue Distribution
Ultrasonics
Chitosan chemistry
Drug Delivery Systems methods
Fluorocarbons pharmacology
Hemolysis drug effects
Magnetic Resonance Imaging methods
Microbubbles
Theranostic Nanomedicine
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 129
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 25819364
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2015.03.023