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Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy.
- Source :
-
Veterinary parasitology [Vet Parasitol] 2015 Apr 30; Vol. 209 (3-4), pp. 273-7. Date of Electronic Publication: 2015 Mar 12. - Publication Year :
- 2015
-
Abstract
- The increasing reports of Aelurostrongylus abstrusus infection and the new information on Troglostrongylus brevior have spurred the interest of the scientific community towards the research of pharmaceutical compounds effective against both pathogens. A novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline®, Merial) has been released for the treatment of a variety of feline parasitic infections. The present study reports the efficacy of this spot-on in treating cats naturally infected by feline lungworms. Client owned cats (n=191) were enrolled from three geographical areas of Italy and faecal samples were examined by floatation and Baermann techniques. Twenty-three individuals were positive for L1 of A. abstrusus (n=18) or T. brevior (n=3) or for both species (n=2) and they were topically treated with Broadline®. Seventeen of them were also concomitantly infected by other parasites. Four weeks after treatment, faecal samples were collected and examined to assess the efficacy of a single administration of the product. Based on lungworm larvae counts, the efficacy of the treatment was 90.5% or 100% for A. abstrusus or T. brevior, respectively. Cats released significantly lower amounts of lungworm larvae after treatment compared to pre-treatment (p<0.0001). All but three cats were negative for other nematodes after treatment and all cats recovered from respiratory signs. Results of this study indicate that a single administration of the topical combination fipronil, (S)-methoprene, eprinomectin and praziquantel is effective and safe for the treatment of A. abstrusus and/or T. brevior infections in cats living under field conditions.<br /> (Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Administration, Topical
Animals
Anthelmintics administration & dosage
Anthelmintics pharmacology
Antiparasitic Agents administration & dosage
Antiparasitic Agents pharmacology
Cat Diseases drug therapy
Cat Diseases epidemiology
Cats
Drug Combinations
Female
Italy epidemiology
Ivermectin administration & dosage
Ivermectin therapeutic use
Male
Metastrongyloidea
Methoprene administration & dosage
Praziquantel administration & dosage
Pyrazoles administration & dosage
Strongylida Infections drug therapy
Strongylida Infections epidemiology
Treatment Outcome
Cat Diseases parasitology
Ivermectin analogs & derivatives
Methoprene therapeutic use
Praziquantel therapeutic use
Pyrazoles therapeutic use
Strongylida Infections veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2550
- Volume :
- 209
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Veterinary parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 25819917
- Full Text :
- https://doi.org/10.1016/j.vetpar.2015.02.037