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Implantable cardioverter-defibrillators and subsequent cancer risk: a nationwide population-based cohort study.
- Source :
-
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology [Europace] 2015 Jun; Vol. 17 (6), pp. 902-8. Date of Electronic Publication: 2015 Apr 02. - Publication Year :
- 2015
-
Abstract
- Aims: Despite increasing use of implantable cardioverter-defibrillators (ICDs) and reports linking selected bio-implants with cancer, the cancer risk associated with implanted ICDs remains unknown. The objective of our study was to examine cancer risk among ICD recipients.<br />Methods and Results: We conducted a population-based cohort study using medical registries covering the entire Danish population. We identified all first-time ICD recipients during the period of 2000-11 and determined their subsequent cancer incidence. Standardized incidence ratios (SIRs) were computed by comparing observed cancer incidence in the ICD cohort with expected cancer incidence based on national incidence rates according to age, sex, and year of diagnosis. A total of 6723 ICD recipients were followed for up to 12 years (median 2.8 years) and contributed a total of 23 254 person-years of follow-up. Compared with the general population, ICD recipients had a slightly elevated overall risk of cancer [SIR = 1.1 (95% confidence interval (CI): 1.0-1.2)]. This was driven by the cancer risk among patients with ischaemic heart disease (IHD) [SIR = 1.1 (95% CI: 1.0-1.3)], which, as expected, was particularly elevated for tobacco-related cancers [SIR = 1.4 (95% CI: 1.2-1.6)]. Importantly, ICD recipients without IHD were not at increased cancer risk [SIR = 1.0 (95% CI: 0.8-1.3)].<br />Conclusion: This nationwide population-based cohort study with up to 12-year follow-up did not indicate a causal relation between ICD implantation and cancer. However, more follow-up data are needed to entirely rule out risks for individual cancer types.<br /> (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Cohort Studies
Colorectal Neoplasms epidemiology
Colorectal Neoplasms etiology
Denmark epidemiology
Esophageal Neoplasms epidemiology
Esophageal Neoplasms etiology
Female
Follow-Up Studies
Humans
Incidence
Infant
Infant, Newborn
Kidney Neoplasms epidemiology
Kidney Neoplasms etiology
Lung Neoplasms epidemiology
Lung Neoplasms etiology
Male
Middle Aged
Risk Factors
Stomach Neoplasms epidemiology
Stomach Neoplasms etiology
Tobacco Use adverse effects
Tracheal Neoplasms epidemiology
Tracheal Neoplasms etiology
Urinary Bladder Neoplasms epidemiology
Urinary Bladder Neoplasms etiology
Young Adult
Defibrillators, Implantable statistics & numerical data
Myocardial Ischemia epidemiology
Neoplasms epidemiology
Registries
Tobacco Use epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2092
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 25840286
- Full Text :
- https://doi.org/10.1093/europace/euv076