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[Evaluating the mitochondrial dna copy number in leukocytes and adipocytes from metabolic syndrome patients: pilot study].

Authors :
Mozheĭ OI
Zatolokin PA
Vasilenko MA
Litvinova LS
Kirienkova EV
Mazunin IO
Source :
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2014 Jul-Aug; Vol. 48 (4), pp. 677-81.
Publication Year :
2014

Abstract

The metabolic syndrome is a complex of metabolic, hormonal and clinical disorders. Defects in mitochondrial functions play an important role in the metabolic syndrome pathogenesis. Here, mitochondrial DNA (mtDNA) copy number variations were evaluated different fat tissue and peripheral blood leukocyte samples from metabolic syndrome patients ranked by, body mass indexes. It was elucidated a tendency in decreasing the mtDNA copy number with increasing a body mass index.

Details

Language :
Russian
ISSN :
0026-8984
Volume :
48
Issue :
4
Database :
MEDLINE
Journal :
Molekuliarnaia biologiia
Publication Type :
Academic Journal
Accession number :
25842851