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Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2015 Sep; Vol. 116 (3), pp. 388-91. Date of Electronic Publication: 2015 Apr 02. - Publication Year :
- 2015
-
Abstract
- Solid tumors contain regions of chronic and cyclic hypoxia. Chronic hypoxia can downregulate RAD51 and sensitize cells to PARP inhibition. Herein, we show that RAD51 expression, cell survival and toxicity to PARP inhibition is not affected under cyclic hypoxic conditions. This suggests that PARP inhibition may be selectively toxic in tumor sub-regions associated with chronic hypoxia.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 116
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25842967
- Full Text :
- https://doi.org/10.1016/j.radonc.2015.03.027