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[Comparative analysis of ionizing radiation and xenobiotics influence on spermatogenic epithelium and dominant lethal mutations output in laboratory animals].
[Comparative analysis of ionizing radiation and xenobiotics influence on spermatogenic epithelium and dominant lethal mutations output in laboratory animals].
- Source :
-
Meditsina truda i promyshlennaia ekologiia [Med Tr Prom Ekol] 2014 (11), pp. 26-9. - Publication Year :
- 2014
-
Abstract
- The study covered state of spermatogenic epithelium and dominant lethal mutations output in mice of BALB/c and CBA lines, subjected to total gamma-irradiation and in Wistar rats after intraperitoneal injection of potassium bichromate (K2Cr2,O7) in small and sublethal doses. The BALB/c line mice under low irradiation dose (0.25 Gy) demonstrated stimulation effect on spermatogenic epithelium, but in the CBA line mice no such effect was seen. Both mice lines under irradiation of 0.25 Gy and 1.0 Gy demonstrated increase in pathologic sperm counts and in percentage ofpreimplantation embryonal death. In rats, injection of potassium bichromate in doses of 0.028 mg/kg and 2.8 mg/kg increased number of micronuclear spermatids, larger pathologic sperm counts and percentage of postimplantation deaths. Thus, lower general embryonal deaths under radiation exposure is due to preimplantation embryonal deaths, under exposure to 6-valent chromium--is due to postimplantation losses.
- Subjects :
- Animals
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Embryo Loss chemically induced
Embryo Loss etiology
Embryo Loss genetics
Female
Male
Mice, Inbred BALB C
Mice, Inbred CBA
Mutation
Pregnancy
Rats, Wistar
Spermatids drug effects
Spermatids radiation effects
Spermatogenesis drug effects
Spermatogenesis genetics
Spermatogenesis radiation effects
Spermatozoa drug effects
Spermatozoa pathology
Spermatozoa radiation effects
Whole-Body Irradiation
Gamma Rays adverse effects
Genes, Dominant drug effects
Genes, Dominant radiation effects
Genes, Lethal drug effects
Genes, Lethal radiation effects
Potassium Dichromate toxicity
Seminiferous Epithelium drug effects
Seminiferous Epithelium pathology
Seminiferous Epithelium radiation effects
Xenobiotics toxicity
Subjects
Details
- Language :
- Russian
- ISSN :
- 1026-9428
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Meditsina truda i promyshlennaia ekologiia
- Publication Type :
- Academic Journal
- Accession number :
- 25845146