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NOD1 in contrast to NOD2 functional polymorphism influence Chlamydia trachomatis infection and the risk of tubal factor infertility.
- Source :
-
Pathogens and disease [Pathog Dis] 2015 Feb; Vol. 73 (1), pp. 1-9. Date of Electronic Publication: 2015 Jan 11. - Publication Year :
- 2015
-
Abstract
- Intracellular pattern-recognition receptors NOD1 and NOD2 are capable of sensing common structural units of bacterial walls. Recognition triggers specific immune signalling pathways and leads to pro-inflammatory cytokine upregulation and adequate immune response. We investigated whether two functional polymorphisms in NOD1 and NOD2 exert an effect on susceptibility to (STD patients) and severity of (female patients visiting the fertility clinic) Chlamydia trachomatis infection in 807 Dutch Caucasian women. A significant association of the NOD1 +32656 GG insertion variant with protection against infection with C. trachomatis has been detected [p: 0.0057; OR: 0.52]. When comparing C. trachomatis-positive women without symptoms to C. trachomatis-positive women with symptoms, and to C. trachomatis-positive women with TFI, we observed an increasing trend in carriage of the GG allele [Ptrend: 0.0003]. NOD2 1007fs failed to reveal an association. We hypothesize that the underlying mechanism might be a functional effect of the GG insertion on IFN-beta-dependent regulation of immune response in the genital tract. The research is part of an ongoing effort of identifying key polymorphisms that determine the risk of TFI and effectively translating them into the clinical setting for the purpose of optimizing diagnostic management of women at risk for developing TFI.<br /> (© The Author 2015. Published by Oxford University Press on behalf of FEMS. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Female
Humans
Netherlands
Polymorphism, Genetic
Retrospective Studies
Risk Assessment
Young Adult
Chlamydia Infections complications
Chlamydia Infections immunology
Chlamydia trachomatis immunology
Genetic Predisposition to Disease
Infertility epidemiology
Nod1 Signaling Adaptor Protein metabolism
Nod2 Signaling Adaptor Protein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2049-632X
- Volume :
- 73
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pathogens and disease
- Publication Type :
- Academic Journal
- Accession number :
- 25854006
- Full Text :
- https://doi.org/10.1093/femspd/ftu028