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Adult body size and physical activity in relation to risk of breast cancer according to tumor androgen receptor status.
- Source :
-
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2015 Jun; Vol. 24 (6), pp. 962-8. Date of Electronic Publication: 2015 Apr 08. - Publication Year :
- 2015
-
Abstract
- Background: Obesity and physical activity have been hypothesized to affect breast cancer risk partly via the androgen signaling pathway. We conducted the first study to evaluate these associations by tumor androgen receptor (AR) status.<br />Methods: Height, weight, and physical activity were assessed using questionnaires in the Nurses' Health Study. AR, estrogen receptor (ER), and progesterone receptor (PR) status were determined using immunohistochemistry on tumor tissue and medical/pathology reports.<br />Results: A total of 1,701 AR(+) and 497 AR(-) cases were documented during 26 years of follow-up of 103,577 women. After adjusting for ER/PR status and other risk factors, the relative risks (RR) and 95% confidence intervals (95% CI) for every 5 kg/m(2) increase in body mass index (BMI) were 1.07 (1.01-1.13) for AR(+) and 1.16 (1.05-1.29) for AR(-) tumors (P-heterogeneity = 0.17). The RRs (95% CIs) per 5 hours of brisk walking/week were 0.87 (0.73-1.04) for AR(+) and 0.67 (0.45-0.99) for AR(-) tumors (P-heterogeneity = 0.22). Further, BMI, but not physical activity, associations differed significantly across ER/PR/AR subtypes (P-heterogeneity = 0.04 and 0.63, respectively). The RRs (95% CIs) for 5 kg/m(2) increase in BMI were 1.23 (1.04-1.45) for ER(+)PR(+)AR(-), 1.19 (1.01-1.39) for ER(-)PR(-)AR(-), 1.15 (1.08-1.23) for ER(+)PR(+)AR(+), and 0.88 (0.75-1.03) for ER(+)PR(-)AR(+) tumors.<br />Conclusions: Higher BMI was associated with an increased risk of both AR(+) and AR(-) breast tumors in postmenopausal women, whereas physical activity, including brisk walking, was associated with a reduced risk of both subtypes. In addition, a significant positive association was observed between higher BMI and ER(-)PR(-)AR(-) tumors.<br />Impact: The similar associations observed by AR status suggest that mechanisms other than androgen signaling underlie these two breast cancer risk factors.<br /> (©2015 American Association for Cancer Research.)
- Subjects :
- Adult
Age Factors
Body Weight
Breast Neoplasms pathology
Female
Follow-Up Studies
Humans
Immunoenzyme Techniques
Middle Aged
Motor Activity
Neoplasm Staging
Nursing Staff
Obesity complications
Postmenopause
Prognosis
Receptors, Estrogen metabolism
Receptors, Progesterone metabolism
Risk Factors
Biomarkers, Tumor metabolism
Body Size
Breast Neoplasms etiology
Breast Neoplasms metabolism
Exercise
Receptors, Androgen metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7755
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25855627
- Full Text :
- https://doi.org/10.1158/1055-9965.EPI-14-1429