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A bivalent cationic dye enabling selective photo-inactivation against Gram-negative bacteria.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2015 May 07; Vol. 51 (37), pp. 7923-6. - Publication Year :
- 2015
-
Abstract
- A piperazine-modified Crystal Violet was found to be able to selectively inactivate Gram-negative bacteria upon visible light irradiation but left Gram-positive bacteria less damaged, which can serve as a blueprint for the development of novel narrow-spectrum agents to replenish the current arsenal of photodynamic antimicrobial chemotherapy (PACT).
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents radiation effects
Cations chemistry
Cations pharmacology
Cations radiation effects
Dose-Response Relationship, Drug
Gentian Violet chemistry
Gentian Violet radiation effects
Gram-Negative Bacteria cytology
Gram-Positive Bacteria cytology
Gram-Positive Bacteria drug effects
Gram-Positive Bacteria radiation effects
Light
Microbial Sensitivity Tests
Molecular Structure
Photochemical Processes
Piperazine
Structure-Activity Relationship
Anti-Bacterial Agents pharmacology
Gentian Violet pharmacology
Gram-Negative Bacteria drug effects
Gram-Negative Bacteria radiation effects
Photochemotherapy
Piperazines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 51
- Issue :
- 37
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 25857842
- Full Text :
- https://doi.org/10.1039/c5cc00174a