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Pancreatic adenocarcinoma up-regulated factor expression is associated with disease-specific survival in cervical cancer patients.
- Source :
-
Human pathology [Hum Pathol] 2015 Jun; Vol. 46 (6), pp. 884-93. Date of Electronic Publication: 2015 Mar 11. - Publication Year :
- 2015
-
Abstract
- Pancreatic adenocarcinoma up-regulated factor (PAUF) is a novel soluble protein involved in tumor development and metastases. This study was to investigate the PAUF expression and its prognostic value in cervical cancer patients. The expression of PAUF was immunohistochemically determined in 345 formalin-fixed, paraffin-embedded cervical cancer tissues and 107 normal cervical epitheliums. Subsequently, its associations with clinicopathological characteristics and patient survival were assessed. PAUF protein was expressed both in cytoplasm and nucleus, and cytoplasmic expression was more frequent in cancers than normal tissues (32% versus 17%, P = .002), and the difference was prominent in glandular cells. Notably, the expression was more frequent in adenocarcinoma than in squamous cell carcinoma (57% versus 25%, respectively; P < .001), and the differential expression was also seen at the messenger RNA level (P = .014). Cox regression analysis showed that the cytoplasmic expression of PAUF protein was independently associated with poor disease-free (hazard ratio = 2.3; 95% confidence interval, 1.2-4.3; P = .008) and overall survival (hazard ratio = 2.9; 95% confidence interval, 1.2-7.5; P = .020). Detection of PAUF expression may aid current evaluation of prognosis in cervical adenocarcinoma.<br /> (Published by Elsevier Inc.)
- Subjects :
- Adenocarcinoma pathology
Adult
Aged
Cell Line, Tumor
Cell Nucleus metabolism
Female
Humans
Middle Aged
Pancreatic Neoplasms complications
Pancreatic Neoplasms pathology
Prognosis
Up-Regulation
Uterine Cervical Neoplasms complications
Uterine Cervical Neoplasms pathology
Pancreatic Neoplasms
Adenocarcinoma diagnosis
Gene Expression Regulation, Neoplastic physiology
Pancreatic Neoplasms diagnosis
Pancreatic Neoplasms mortality
Uterine Cervical Neoplasms diagnosis
Uterine Cervical Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8392
- Volume :
- 46
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 25870121
- Full Text :
- https://doi.org/10.1016/j.humpath.2015.02.016