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MicroRNAs regulate bone development and regeneration.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2015 Apr 13; Vol. 16 (4), pp. 8227-53. Date of Electronic Publication: 2015 Apr 13. - Publication Year :
- 2015
-
Abstract
- MicroRNAs (miRNAs) are endogenous small noncoding ~22-nt RNAs, which have been reported to play a crucial role in maintaining bone development and metabolism. Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone formation is inseparable from the delicate regulation of various miRNAs. Of note, apprehending the sophisticated circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone defects. In this review, we highlight how different miRNAs interact with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair.
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25872144
- Full Text :
- https://doi.org/10.3390/ijms16048227