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Transition-metal-free trifluoromethylthiolation of N-heteroarenes.

Authors :
Honeker R
Ernst JB
Glorius F
Source :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2015 May 26; Vol. 21 (22), pp. 8047-51. Date of Electronic Publication: 2015 Apr 14.
Publication Year :
2015

Abstract

A general and efficient methodology for the direct transition metal free trifluoromethylthiolation of a broad range of biologically relevant N-heteroarenes is reported employing abundant sodium chloride as the catalyst. This method is operationally simple, exhibits high functional group tolerance, and does not require protecting groups.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1521-3765
Volume :
21
Issue :
22
Database :
MEDLINE
Journal :
Chemistry (Weinheim an der Bergstrasse, Germany)
Publication Type :
Academic Journal
Accession number :
25873557
Full Text :
https://doi.org/10.1002/chem.201500957