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Herpes virus entry mediator, which decreases in HIV infection, can enhance the suppressive activity of regulatory T cell and predict recovery of CD4+T-cells during HAART.
- Source :
-
Current HIV research [Curr HIV Res] 2015; Vol. 13 (2), pp. 151-9. - Publication Year :
- 2015
-
Abstract
- Co-signaling molecules have been demonstrated to regulate regulatory T cells' (Tregs) function during human immunodeficiency virus (HIV) infection. A recently reported co-signaling molecule called herpes virus entry mediator (HVEM), a member of the tumor necrosis factor receptor family, can both enhance and inhibit the immune response. HVEM was also reported to enhance the suppressive function of regulatory T cells in mice. However, it remains unknown whether HVEM can regulate Treg function in HIV-infected patients or whether HVEM affects HIV disease progression. In this study, we found that the blockage of the HVEM could weaken Tregs' suppressive activity to effector T cells (Teffs). HVEM expression is reduced during the asymptomatic phase of HIV infection and fairly predictive of the recovery of CD4+T-cells in response to highly active anti-retroviral therapy (HAART), more so than nadir CD4+T-cell count or viral load. Taken together, these findings demonstrate the importance of HVEM in relation to Treg function and HIV disease progression, which would have therapeutic implications and provide insight into the pathogenesis of acquired immune deficiency syndrome (AIDS).
- Subjects :
- Acquired Immunodeficiency Syndrome etiology
Adult
Animals
Anti-HIV Agents therapeutic use
Disease Progression
Female
Herpesvirus 1, Human immunology
Humans
Male
Mice
Middle Aged
Receptors, Tumor Necrosis Factor, Member 14 metabolism
T-Lymphocytes, Regulatory metabolism
Antiretroviral Therapy, Highly Active
CD4-Positive T-Lymphocytes immunology
HIV Infections drug therapy
HIV Infections immunology
HIV Infections metabolism
Herpesvirus 1, Human physiology
Lymphocyte Activation
Receptors, Tumor Necrosis Factor, Member 14 immunology
T-Lymphocytes, Regulatory immunology
Virus Internalization
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4251
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current HIV research
- Publication Type :
- Academic Journal
- Accession number :
- 25892413
- Full Text :
- https://doi.org/10.2174/1570162x1302150415110714