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Kinetics of aggregation and crystallization of polyaspartic Acid stabilized calcium phosphate particles at high concentrations.
- Source :
-
Biomacromolecules [Biomacromolecules] 2015 May 11; Vol. 16 (5), pp. 1550-5. Date of Electronic Publication: 2015 May 01. - Publication Year :
- 2015
-
Abstract
- Bone is an important material to study due to its exceptional mechanical properties and relevance with respect to hard tissue regeneration and repair. A significant effort has been directed toward understanding the bone formation process and the production of synthetic bone mimicking materials. Here, the formation and structural evolution of calcium phosphate (CaP) was investigated in the presence of relatively high concentrations of calcium, phosphate, and polyaspartic acid (pAsp) using dynamic light scattering (DLS) and cryo-transmission electron microscopy (cryo-TEM). The incipient CaP aggregates were comprised of spherical nanoparticles (diameter ≈ 3-4 nm); they became preferentially aligned over time and eventually transformed into nanorods. The nanorods remained stable in suspension with no signs of further aggregation for at least four months. Detailed cryo-TEM suggested that the CaP nanorods formed through an oriented attachment mechanism. These results show that the reaction concentration greatly influences the mechanism and final properties of CaP. Mechanistic insights gained from this study will facilitate better design and fabrication of bioinspired materials.
- Subjects :
- Biomimetic Materials chemistry
Cryoelectron Microscopy
Crystallization
Humans
Kinetics
Microscopy, Electron, Transmission
Nanoparticles ultrastructure
Nanotubes chemistry
Nanotubes ultrastructure
Bone and Bones chemistry
Calcium Phosphates chemistry
Nanoparticles chemistry
Peptides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1526-4602
- Volume :
- 16
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 25901665
- Full Text :
- https://doi.org/10.1021/bm501725t