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Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
- Source :
-
Nature communications [Nat Commun] 2015 Apr 23; Vol. 6, pp. 6916. Date of Electronic Publication: 2015 Apr 23. - Publication Year :
- 2015
-
Abstract
- Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis in 15,369 cases and 19,517 controls of Caucasian and Chinese ancestries. We identify four novel associations at LOC144817, COG6, RUNX1 and TP63, as well as three novel secondary associations within IFIH1 and IL12B. Fine-mapping analysis of MHC region demonstrates an important role for all three HLA class I genes and a complex and heterogeneous pattern of HLA associations between Caucasian and Chinese populations. Further, trans-ethnic comparison suggests population-specific effect or allelic heterogeneity for 11 loci. These population-specific effects contribute significantly to the ethnic diversity of psoriasis prevalence. This study not only provides novel biological insights into the involvement of immune and keratinocyte development mechanism, but also demonstrates a complex and heterogeneous genetic architecture of psoriasis susceptibility across ethnic populations.
- Subjects :
- Adaptor Proteins, Vesicular Transport genetics
Case-Control Studies
Core Binding Factor Alpha 2 Subunit genetics
DEAD-box RNA Helicases genetics
Genes, MHC Class I genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Interferon-Induced Helicase, IFIH1
Interleukin-12 Subunit p40 genetics
Transcription Factors genetics
Tumor Suppressor Proteins genetics
Asian People genetics
Psoriasis genetics
White People genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 25903422
- Full Text :
- https://doi.org/10.1038/ncomms7916