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A new cycloartane glucoside from Rhizophora stylosa.
- Source :
-
Natural product communications [Nat Prod Commun] 2014 Sep; Vol. 9 (9), pp. 1255-7. - Publication Year :
- 2014
-
Abstract
- Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY) and HR-ESI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.
- Subjects :
- Caspase 3 genetics
Caspase 3 metabolism
Caspase 7 genetics
Caspase 7 metabolism
Cell Line, Tumor
Glucosides isolation & purification
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Neoplasms enzymology
Neoplasms genetics
Plant Extracts isolation & purification
Glucosides chemistry
Plant Extracts chemistry
Rhizophoraceae chemistry
Triterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1934-578X
- Volume :
- 9
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Natural product communications
- Publication Type :
- Academic Journal
- Accession number :
- 25918786